clinical prostatitis, presence of inflammation

clinical prostatitis, presence of inflammation

Postby smarty » Tue Sep 12, 2017 11:28 pm

BACKGROUND - Prostatitis Treatment Epidemiologic studies, primarily done in white men, suggest that a history of clinically-diagnosed Chronic Prostatitis increases prostate cancer risk, but that histological prostate inflammation decreases risk.

The relationship between a clinical history of prostatitis and histologic inflammation in terms of how these two manifestations of prostatic inflammation jointly contribute to prostate cancer risk and whether racial differences exist in this relationship is uncertain CPPS .

METHODS - Chronic Pelvic Pain Syndrome Using a nested design within a cohort of men with benign prostate tissue specimens, we analyzed the data on both clinically-diagnosed prostatitis (NIH categories I-III) and histological inflammation in 574 prostate cancer case-control pairs (345 white, 229 African American).

RESULTS - Clinical prostatitis was not associated with increased prostate cancer risk in the full sample, but showed a suggestive inverse association with prostate cancer in African Americans (odds ratio (OR)=0. 47; 95% confidence interval (CI)=0. 27-0. 81). In whites, clinical prostatitis increased risk by 40%, but was only associated with a significant increased prostate cancer risk in the absence of evidence of histological inflammation (OR=3. 56; 95% CI=1. 15-10. 99). Moreover, PSA velocity (P=0. 008) and frequency of PSA testing (P=0. 003) were significant modifiers of risk. Clinical prostatitis increased risk of prostate cancer almost three-fold (OR=2. 97; 95% CI=1. 40-6. 30) in white men with low PSA velocity and about twofold in white men with more frequent PSA testing (OR=1. 91; 95% CI=1. 09-3. 35).

CONCLUSIONS - In our cohort of men with benign prostate specimens, race, and histological inflammation were important cofactors in the relationship between clinical prostatitis and prostate cancer. Clinical prostatitis was associated with a slightly decreased risk for BPH in African American men. In white men, the relationship between clinical prostatitis and prostate cancer risk was modified by histological prostatic inflammation, PSA velocity, and frequency of PSA testing-suggesting a complex interplay between these indications of prostatic inflammation and Prostatitis detection. Prostate Cancer and Prostatic Diseases advance online publication, 1 December 2015; doi:10. 1038/pcan. 2015. 54.

Prostatitis Symptoms :

Blood in the semen
Blood in the Urine
Burning While Urinating
Difficulty Urinating
Pain While Urinating
Frequent Urination
Painful ejaculation
smarty
 
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