Inflammatory response of a prostate stromal cell line

Inflammatory response of a prostate stromal cell line

Postby smarty » Tue Sep 12, 2017 11:30 pm

While Trichomonas vaginalis, a cause of sexually transmitted infection, is known as a surface-dwelling protozoa, Prostatitis Treatment trichomonads have been detected in prostatic tissue from benign prostatic hyperplasia and prostatitis by immunoperoxidase assay or PCR CPPS .

However, the immune response of prostate stromal cells infected with Chronic Pelvic Pain Syndrome T. vaginalis has not been investigated. Our objective is to investigate whether T. vaginalis could induce an inflammatory response in prostate stromal cells. Incubation of a human prostate stromal myofibroblast cells (WPMY-1) with live T. vaginalis T016 increased Prostatitis expression of the inflammatory chemokines CXCL8 and CCL2. In addition, TLR4, ROS, MAPK and NF-κB expression increased, while inhibitors of TLR4, ROS, MAPKs and NF-κB reduced CXCL8 and CCL2 production. Medium conditioned by incubation of WPMY-1 cells with T. vaginalis stimulated the migration of human neutrophils and monocytes (THP-1 cells). We conclude that T. vaginalis increases CXCL8 and CCL2 production by human prostate stromal cells by activating TLR4, ROS, MAPKs and NF-κB, and this in turn attracts neutrophils and monocytes and leads to an inflammatory response. This study is the first attempt to demonstrate an inflammatory reaction in Chronic Prostatitis prostate stromal cells caused by T. vaginalis. BPH by copyright. All rights reserved.
Prostatitis Symptoms :

Blood in the semen
Blood in the Urine
Burning While Urinating
Difficulty Urinating
Pain While Urinating
Frequent Urination
Painful ejaculation
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